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Sperm cells are particularly susceptible to oxidative and reductive imbalances because of their structural features, which include a high membrane concentration of polyunsaturated fatty acids, weak antioxidant defenses, and rapid metabolic activity [4]

11-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5-reductase yielding 11-hydroxy-5-androstanedione

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