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Carcinogen Detoxification: By conjugating with and neutralizing various carcinogens, GSTs serve as a critical defense mechanism, reducing the risk of DNA damage and subsequent cancer development

Weeks Tirzepatide dose Notes 14 2.5 mg Initiation only (not for glucose/weight effect) 58 5 mg First maintenance option 912 7.5 mg Increase as tolerated 1316 10 mg Maintenance option 1720 12.5 mg Increase as tolerated 21+ 15 mg (max) Maximum maintenance dose These steps follow the Mounjaro FDA label and Zepbound FDA label

doi: 10.1016/j.fshw.2016.04.001 73

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