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Occurrence of the identified variants was assessed using the 1000 Genomes project browser ( the NHLBI Exome Sequencing Project Exome Variant Server database (release ESP6500, the Exome Aggregation Consortium ( and the EDS Variant database ( Expression analysis Quantitative PRC (qPCR) primers were designed for ADAMTS2 and three reference genes ( HPRT1 , RPL13A , and YWHAZ)

GHK-CU levels naturally decrease with age, contributing to slower healing, reduced collagen production, and diminished cellular function