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[1] [2] While high-dose oral B12 supplements can be effective through passive diffusion, they are not routinely recommended for pernicious anaemia management in UK practice

In two trials employing 1000 g/day oral vitamin B 12 , there was no clinically relevant difference in vitamin B 12 levels when compared with IM vitamin B 12

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The British Society for Haematology emphasises that treatment should not be delayed whilst awaiting confirmatory test results if clinical suspicion of B12 deficiency is high, particularly when neurological symptoms are present