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In tissues, the ketosteroid isomerase reactions catalyzed by GSTs are strictly dependent on dehydrogenases such as 3-hydroxysteroid dehydrogenase and 17-hydroxysteroid dehydrogenase for production of the 3-keto substrates from the corresponding 3-hydroxysteroid precursors, since the GSTs are lacking dehydrogenase activity

Whitlock BK, Daniel JA, Wilborn RR, Maxwell HS, Steele BP, Sartin JL

Int J Mol Sci (2019) 20(24):6268

This is important for both research and clinical translation, as it shifts the focus from observing disease to understanding the biological pathways behind it