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This situation occurs in chronic diseases such as hypertension, ischemic heart disease, and atherosclerosis 3,8,73

33 The biology of MTs is characterized by zinc binding, movement within the cell, and transportation of zinc to various cellular compartments, including extracellular, endosomal, nuclear, and mitochondria

In an in vitro co-culture model, astrocyte-derived transforming growth factor-1 upregulated the expression of the tight junction protein zonula occludens-1 in brain microvascular endothelial cells and reinforced endothelial barrier function through non-canonical hedgehog signaling [90]

77 Shahidi S et al