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Joint Pain Symptoms Joint pain may have the following signs and symptoms: Joint bruising Red and swollen joints Bruising Joint stiffness Warmth around the joint Difficulties when bending or straightening the joints Tingling or numbing sensation Joint tenderness Limping Loss of joint range of motion Joint locking When to See a Doctor See your doctor if there is swelling, tenderness, warmth to the touch, and redness in the joint

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Structure of the p53 degradation complex from HPV16