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It works by binding to GHRH receptors in the pituitary gland, stimulating the natural release of human growth hormone (GH), which then increases circulating levels of IGF-1 (Insulin-like Growth Factor-1)

The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

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Sam is an avid weekend soccer player, and during a match he was tackled from the outside and felt a sharp pain along the inside of his knee