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Research has shown that the area under the concentration-time curve (AUC) correlates linearly with the administered dose, and no significant differences in the pharmacokinetics of AS-IV have been observed between rats and Beagle dogs (Zhang et al., 2007)

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Statistical significance was assessed in GraphPad Prism and tested by one- or two-way ANOVA for repeated measurements followed by Tukeys multiple comparison test, or unpaired one-way ANOVA followed by Tukeys multiple comparison test

Regarding the hemoglobin level, the pooled effect sizes showed no difference between all routes of administration that could reach statistical significance