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These studies suggest that FoxP3 plays distinct roles under natural and forced expression conditions in CD4 + T cells and CD8 + T cells, respectively

Niu et al., 2023)

Pregnancy and lactation safety has not been systematically studied, and as with most cosmetic and research compounds lacking definitive pregnancy safety data, conservative practice typically suggests avoiding use during pregnancy unless clearly needed, though the natural occurrence of GHK-Cu in the body and minimal systemic absorption from topical use suggest risk is likely to be low