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Participants were excluded if they had significant medical histories, abnormal lab results, or conditions affecting alcohol metabolism or absorption of the investigational product

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Future studies could utilize patient-derived human pluripotent stem cells and differentiate them into T cells to decipher the mechanisms that trigger the population shift from nave T cells to other cell types, including CD8+TCF1 high cells, and determine whether these autoreactive T cells can lead to the destruction of cells using human in vitro models