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For neuroprotection, the HGF mimics may be administered propylactically, i.e

Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism

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Aside from fatigue, there are a few other early signs of deficiency you can watch out for: Numbness or tingling in your hands, feet, or legs Always cold or unable to warm up, especially your hands or feet Weakness Ulcers on your gums or tongue Digestive issues such as lack of appetite, unexplained rapid weight loss, or constipation Can You Take B12 While Pregnant