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Chandy thinks the phenomenon occurs because the B12 allows the body to put itself right, and if you have had things wrong for a long time, then theres a lot to put right in a small period of time

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In animal models, L-theanine appears to have a dose-dependent biphasic effect on NSAID-induced gastric ulcers, delaying healing at higher doses (40 mg/kg), but accelerating healing at lower doses (10 mg/kg) perhaps through the maintenance of glutathione levels thus protecting against oxidative damage (26)

With an IV infusion or with a multiple dose regimen, the rate of drug entry into the body is equal to its elimination rate, and the body becomes a closed system with no clearance