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Introduction into humans or animals is strictly prohibited

More particularly, for each baseline (and progression, respectively) sample, SAMtools version 1.9 mpileup 49 was run on the positions where Mutect2 identified and retained mutations in the corresponding progression (and baseline, respectively) sample to rule out incorrect claims of mutation acquisition or loss caused by conservative filtering or non-detection by Mutect2

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Patients experiencing persistent gastrointestinal adverse effects may benefit from slower titration schedules or maintaining lower doses for longer periods before attempting escalation