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In anticipation of these issues, in 1999 the FDA asked the Institute of Medicine (IOM) to convene a committee of experts to formulate scientific methods and standards by which PREPs (pharmaceutical or tobacco related) could be assessed
In iPSC-EC exposed to e-liquids, evidence of endothelial dysfunction were observed including lower cell viability, higher production of IL-1 and 6, ROS production, activation of OS-related pathway, caspase 3/7 activity, low-density lipoprotein uptake (LDL), and disrupted tube formation and migration [31]
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