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For the entire 20th century, it is estimated that around 100 million people died prematurely because of smoking, most of them in rich countries

Huffing can result in death, from even just one use due to an irregular heartbeat and cardiac arrest asphyxiation where toxic fumes replace all oxygen in the lungs suffocation if a plastic bag is applied over the head after huffing from seizures from choking on vomit after inhalant use

Other non-communicable diseases mediated by air pollution Other chronic cardio-metabolic syndrome-related diseases, including obesity (140), sleep-related respiratory disorders (141), chronic kidney disease (142), along with neurological diseases (e.g., dementia, sadness) (141), have been associated with air contamination, though further study is required