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The majority of injury complaints, particularly those of a sporting nature, result from some form of incomplete or complete tear in the fibres that comprise the structure of the functioning tissue or musculotendinous unit (Sloan 2008)

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The power to detect differences between the study groups is larger than what is projected here as we will measure most of the outcomes more than once and also use these repeated measurements in the same analyses, adjusting for interdependence within a child using mixed effects models, generalised estimating equations or other appropriate methods

The full 12-week schedule requires 5660 injections, depending on whether the maintenance phase is dosed two or three times weekly