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A study of 6522 patients found that 24 (0.4%) had experienced adverse reactions, the most frequent being anorexia, nausea, vomiting, and rash [29]

When miR-192 is absent or inhibited, SREBF1 expression is increased, leading to enhanced de novo lipogenesis and promoting the development of MASLD [315]

27 Importantly, GLP-1 action is short-lived, with a half-life of just 12 minutes in the bloodstream under normal physiological conditions, after which it is broken down by the enzyme dipeptidyl peptidase IV (DPP-4), resulting in a loss of its biological activity