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A more strategic clinical decision is to maintain the GLP-1 at a tolerable maintenance dose to control appetite, and introduce a complementary mechanism

It interacts with multiple pathways, including those regulating angiogenesis, collagen synthesis, and inflammation

Fine-line softening and initial firming emerge from week 6 to 8 as new collagen synthesis ramps up under GHK-Cu and PDRN influence

Notably, ILC2 proportions were comparable between IL-33 alone and IL-33 plus melatonin and Luzindole groups ( Figures 2K, L ), yet BALF concentrations of IL-5 ( Figures 2M ) and IL-13 ( Figures 2N ) remained significantly reduced with melatonin treatment, again indicating dampened ILC2 activity rather than altered ILC2 abundance