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Incorporating ONPs into tobacco control frameworks, especially in low- and middle-income countries where cessation support is scarce, represents both an urgent and ethical opportunity to accelerate progress toward ending combustible tobacco use

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Start at the cupholders to pull off the trim and you can use a butter knife to help pop it off easier if you have access to one

One methodological issue that might explain why so few studies have directly examined this important question pertains to the need for relatively large sample sizes to be adequately powered for interaction, or moderation, analyses