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aureus strains LAC, HG003, MW2, JE2, JE2-lux (JE2 lux ABDCE) (kindly provided by Roger Plaut, Center for Biologics Evaluation and Research, Silver Spring) 28 , G4 (kindly provided by Anthony Richardson, University of Pittsburgh, Pittsburgh) 35 and bacteraemia isolates 8 were routinely cultured in tryptic soy broth (TSB, Fisher Scientific) or MuellerHinton broth (MHB, Oxoid) at 37 C with shaking (225 r.p.m.) unless otherwise stated

Over the next two to three days that tenderness usually eases

Absorption occurs within minutes

Most users begin with 0.25 mg once daily to assess tolerance before potentially increasing