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In myeloid cell lines there was a more differential effect: when quercetin and apigenin were used in combination with each topoisomerase II inhibitor, there was a synergistic/additive decrease in cell proliferation, cell accumulation in G 2 M and S phase of the cell cycle and an increase in apoptosis
Moreover, hesperetin and hesperidin are reported to directly suppress viral replication in other pathogens such as RSV, zika virus (ZIKV), chikungunya virus (CHIKV), suggesting them as potential broad-spectrum antiviral agents with multi-target mechanisms (302, 303)
Whereas the G6PD encoded enzyme resides in the cytosol, the H6PD encoded enzyme resides within the endoplasmic reticulum (ER) and the sarcoplasmic reticulum (SR)
Airway hyperresponsiveness reflects corticosteroid-sensitive mast cell involvement across asthma phenotypes
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