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Surgery is generally reserved for cases with progressive neurological deficits, cauda equina syndrome (a surgical emergency), or persistent symptoms despite 6 to 12 months of conservative treatment

However, despite its promising mechanisms, AOD-9604 is not FDA-approved for medical use

However, disruption of this equilibrium, for example through the blockage of mitochondrial fusion and fission, may lead to oxidative stress, mitochondrial dysfunction and metabolic alterations, and ultimately to the development of mitochondria-associated diseases (Xiao et al., 2021)

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