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Much of the Semax clinical record consists of open-label or non-randomized designs, modest sample sizes, single-center Russian settings, and outcome measures that are not always blinded features that, by contemporary evidence-based-medicine standards, place the findings well below the bar of a large multicenter randomized controlled trial

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Life Sci 70:603614 Bieschke J, Russ J, Friedrich RP, Ehrnhoefer DE, Wobst H, Neugebauer K, Wanker EE (2010) EGCG remodels mature -synuclein and amyloid- fibrils and reduces cellular toxicity

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