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[DOI] [PubMed] [Google Scholar] Inouye E

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While methylfolate is generally the preferred supplemental form because it bypasses the activation pathway, it is incorrect to conclude that folic acid has no place in clinical practice

When to Seek Medical Attention Contact your healthcare provider if your headache: Becomes progressively worse Persists despite hydration and treatment Interferes significantly with normal activities Recurs after multiple infusions Seek immediate medical attention if your headache is accompanied by: Neck stiffness Fever Confusion or altered mental status Visual disturbances Severe nausea or vomiting Weakness, numbness, or difficulty speaking These symptoms may indicate a more serious complication and require prompt evaluation