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And some people have genetic variants (like CBS, SUOX, or MTHFR) that affect how well they metabolize and excrete sulfur compounds, meaning more gets pushed out through the skin

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Berberine side effects are predominantly gastrointestinal and may include: Diarrhoea, constipation, or abdominal discomfort Nausea and flatulence Cramping or bloating These effects are typically dose-dependent and may be minimised by starting with lower doses and taking berberine with meals

Other diagnoses include genetic mutations, chromosomopathies, tuberous sclerosis, polymicrogyria, cerebral infarction, and developmental speech disorders