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Plasmids and molecular cloning The plasmids Go-GFP WT and Q205L mutant, GalT-GFP, His 6 -RGS19, mRFP-G1, mRFP-G3, and GalT-mRFP for Drosophila expression were previously described 5,48,62

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5-Amino-1MQ reduces white adipose tissue and body weight in preclinical obesity models without affecting appetite, highlighting its direct metabolic actions [8]

120 In the central nervous system, TFEB promotes the clearance of pathogenic protein aggregates, such as -synuclein and tau, by inducing lysosomal hydrolases, including CTSB, GBA , and LAMP2 , contributing to neuroprotection in models of PD and frontotemporal dementia