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Ultimately, this FOXO4-DRI-mediated mechanism selectively eliminates senescent endothelial cells, which in turn attenuates vascular inflammation and improves endothelial-dependent vasodilation, conferring a significant protective effect on vascular function

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Compound 40 effectively inhibited LPS-induced elevation of TNF-, IL-6, iNOS, and COX-2 through the NF-B and MAPK pathways

Braz J Bot 47(3):735750 Golemiec E, Tokarz K, Wielanek M, Niewiadomska E (2014) A dissection of the effects of ethylene, HO and high irradiance on antioxidants and several genes associated with stress and senescence in tobacco leaves