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EIMs of IBD and Their Relationship With IBD Activity EIM Axial arthropathy Peripheral arthropathy Type 1 (pauciarticular) Type 2 (polyarticular) Erythema nodosum Pyoderma gangrenosum Sweet syndrome Oral aphthous ulcers Episcleritis Uveitis PSC Parallels IBD activity Independent of IBD activity May or may not parallel IBD activity Laboratory Findings weight loss, muscle wasting, abdominal tenderness (particularly in the lower abdomen), and a palpable mass, usually in the ileocecal region of the right lower quadrant of the abdomen

The association strengthened with higher B12 levels

Ongoing clinician oversight Provider-guided dosing and check-ins throughout your plan

Without load, healing tissue lacks the directional signals that create strong, functional structure