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Several mutations in the ligand binding domain, detected in patients with the syndrome of androgen insensitivity, negatively affect the interaction of the NH 2 -terminal domain with the ligand binding domain, while androgen binding was impaired, indicating the importance of this interaction (120)

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Idebenone is orally active and has demonstrated some side effects that include vomiting, stomach pain, loose stools, fast heart rate, or increased risk of infection

Additionally, the introduction of new activation functions, such as the LogRelu activation function, and optimization algorithms like the Adam optimizer, has improved training efficiency and convergence [53]