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Description

Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic Inhibitor G0/G1 switch gene 2 (G0S2)

Activation of oncogenes and loss of tumor suppressors lead to the increased production of superoxide via mitochondria and NADPH oxidase (NOX) pathways ( 2 O 2 ), a more stable and stronger oxidizing molecule, through the action of superoxide dismutase enzymes (SOD)