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Overview of the Methodologies Used for the Chemical Analysis of Kava The World Health Organization (WHO) published a monograph recommending the use of high-performance liquid chromatography (HPLC)electrospray mass spectrometry to obtain qualitative analytical profiles and HPLC as the standard method for quantitative analysis [31]

This mechanism enables NAC to diminish glutamatergic tone by enhancing cystine uptake (which serves as a substrate for xCT) and, as a result, facilitating the release of glutamate to stimulate the inhibitory presynaptic metabotropic mGlu2/3 receptor [44]

Hilliard TN, Regamey N, Shute JK et al (2007) Airway remodelling in children with cystic fibrosis