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Neurodegenerative diseases: oxidative stress meets neuroinflammation Role of oxidative stress and neuroinflammation in neurodegenerative diseases Neurodegenerative diseases share common features such as oxidative damage, neuroinflammation, autophagy dysfunction, protein aggregation, and mitochondrial defects [2, 55]

The big difference here is that cancer research, for example, deals with end of life situations, and any such research can take on higher risks than when dealing with perfectly healthy subjects

The upregulation of BDNF signaling in animal models appears to improve the survival of dopaminergic neurons when given prior to PD induction or result in partial restoration of dopaminergic transmission [230]

Some number of years can go by, and they are still on the medication