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Factors responsible for the liver's contribution to drug metabolism include that it is a large organ, that it is the first organ perfused by chemicals absorbed in the gut, and that there are very high concentrations of most drug-metabolizing enzyme systems relative to other organs

The following signs in your body can signal a copper deficiency: Pale, light patches of skin Constant tiredness or fatigue Weak bones High cholesterol Problems with your connective tissue Poor balance and coordination Higher risk of infection due to a weakened immune system But its also possible to get too much copper