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However, with the prevalence of skin permeation enhancement methods (such as microneedles and laser) used in cosmetic and pharmaceutical industry 15 , copper compounds may pose a higher risk to cause skin irritation, which necessitates a thorough skin toxicity testing

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J Biol Chem 277:3289232898 Rubi B, del Arco A, Bartley C, Satrustegui J, Maechler P (2004) The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells