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On top of this, an enzyme called carnitine palmitoyltransferase-1 (CPT-1) is freed from additional inhibition, potentially shuttling more fatty acids into mitochondria for burning rather than storage

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In some embodiments, a concentration of the otoprotectant, wherein the otoprotectant is an antioxidant or an anti-apoptotic agent is in a range of about 0.1 M to about 100 M, about 1 M to about 100 M, about 10 M to about 100 M, or about 50 M to about 100 M