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27 Free radical generation In addition, NADPH is also responsible for the generation of free radicals by NADPH oxidases (NOX) as a substrate

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The vacuum inside the vial after reconstitution is intentional it prevents microbial ingress

Current senolytic agents are primarily employed in cancer therapies, such as doxorubicin, trametinib, and cell cycle-targeting drugs like palbociclib (Lea et al., 2022