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coli significantly upregulates the expression of SOD, suggesting that this response fulfills an antioxidant role ( The maintenance of sustained SOD activity is crucial for preserving intracellular redox homeostasis, thereby preventing the excessive accumulation of ROS that could potentially disrupt immune signaling pathways, such as the TLR and interferon pathways

11,12 The 1990s introduced crucial discoveries in endoplasmic reticulum (ER) stress signaling and unfolded protein response (UPR) pathways, establishing ER proteostasis as a cornerstone of metabolic and neurodegenerative disease biology

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