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Based on their amino acid sequence, plant PPOs can be divided into two phylogenetic groups (group 1 and group 2), and it has been shown recently that members of group 1 exhibit mono- and diphenolase activity, whereas group 2 PPOs are only active on diphenols 32,33

Kwon and Park 2015 reported that intra-articular AOD-9604 injections, especially when combined with hyaluronic acid, improved cartilage scores and reduced lameness in a rabbit collagenase-induced osteoarthritis model

doi: 10.1007/s00204-024-03941-w 98 LaiQLiuF-MRaoW-LYuanG-YFanZ-YZhangLet al