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However, you should make an appointment to see a doctor if: your cold sore has not healed with in 10 days youre concerned that it may be something else (not a cold sore) the cold sore is large and very painful you also have swollen, painful gums, and sores inside your mouth you have a weakened immune system, due to chemotherapy, diabetes, or other health condition you have a red, painful, or swollen eye

Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy

Diabetologia 13 , 117124 (1977)