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The combination of LNS8801 and pembrolizumab (a programmed death-ligand 1 (PD-L1) inhibitor) has entered phase 1/2 clinical trials (NCT04130516), which represents the first clinical study of a treatment targeting GPER for several advanced solid tumors

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To further distinguish heterogeneous conformations observed in the datasets of CTR:Cagri/CagriBB, the authentic particles of complexes were separated into multiple clusters by 3D Classification in cryoSPARC with approximately 50100k particles for each cluster