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Updated individualized doses for days 24 were calculated by scaling the previous dose with the ratio of obtained AUC obs and predefined AUC target using the equation and solving for new dose as follows: Dose administered in mg/AUC obs = new dose in mg/desired AUC target

Within the quinone family of compounds, the most frequently applied skin-whitening agents are hydroquinone (HQ) (78,79) and arbutin (80,81)

23.2.1 Los signatarios pondrn en prctica las disposiciones aplicables del Cdigo mediante polticas, leyes, normas o reglamentos, en funcin de su autoridad, y dentro de sus respectivos mbitos de competencia