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Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans

The reduction of human RNR, which was suggested to follow mechanism (ii) 46 , therefore needs to be analyzed and monothiol mechanism (iii) should be also considered

Notably, poorly differentiated hepatomas such as, SK-Hep, FOCUS, and PLC/PRF/5 are more glutamine-dependent than HepG2, Hep3B, and Huh-7 cells [34,35]