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Toxic reactions: Because Spice can contain a variety of unknown chemicals, users may experience acute toxicity, leading to severe symptoms like elevated body temperature and increased agitation

Also, weed can have sedative effects that will affect pain perception

So, for their systematic review and meta-analysis, they used data from 141 published studies to calculate the risk of coronary heart disease and stroke for those who smoke one, five, and 20 cigarettes per day compared with never-smokers