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The resulting particles were subjected to non-uniform 3D refinement, followed by a final local Euler angle local refinement to generate the final consensus maps from which the -helical domain (AHD) of the G s protein and the detergent micelle were masked out

As such, the HGF binding properties of a selection of analogs with varying biological activity was assessed to determine if there was a relationship between inhibitory activity and affinity for HGF

While promising, the risk of tumorigenicity and proper cell differentiation of this therapy have yet remained to be carefully investigated

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