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Cellular autophagy and cell death In DPN, hyperglycemia impairs autophagy by inhibiting key autophagy-related proteins, resulting in the accumulation of dysfunctional mitochondria and protein aggregates

This can temporarily make the skin appear duller or slightly worse, as breakdown outpaces synthesis

Oxidative stress, characterized by an imbalance between ROS generation and antioxidant defenses, has been implicated in the pathology of ME/CFS, FM, and GWS (Gottschalk et al., 2022

Furthermore, considering the concurrent increase in 5-HT levels, it is postulated that these polysaccharides may modulate TRP metabolism towards the TRP/5-HT pathway by enhancing TPH enzyme activity and inhibiting IDO enzyme activity