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Phase 3 trials currently underway will provide data on efficacy beyond one year

Then, the hydrogel scaffold is allowed to be set at the ECM compartment around the needle that is removed once the polymerization of the scaffold is finished

A transient breach in the epithelial barrier leads to the resistance to colitis This study was the first direct attempt to understand how physiologic breaks in the mucosal barrier, which must occur for homeostatic regulatory T cells to develop (Figure 1), may differ from the pathological mucosal barrier defects widely implicated in promoting inflammation of the underlying lamina propria