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Challenges include the high cost of production, protracted clinical trial timelines, and the stringent safety and regulatory requirements that must be met

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1,2 In a 2005 Cochrane review, patients who received high dosages of oral vitamin B 12 (1 to 2 mg daily) for 90 to 120 days had an improvement in serum vitamin B 12 similar to patients who received intramuscular injections of vitamin B 12

For instance, fatigue-induced changes in biomechanics, such as increased knee valgus (inward collapse of the knee) and internal rotation, are associated with a higher risk of ACL injuries