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Regarding long-term effects in the general population with a history of smoking, a controlled 1-year follow-up study found that changes in exhaled nitric oxide (FeNO) were significantly correlated with those of exhaled carbon monoxide (COe) throughout the follow-up, mainly a relative increase in the first 3 months followed by a significant increase at 6 and 12 months (53)

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Hazardous compounds in tobacco smoke