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Methods Plant materials and growth condition hairpin RNA-52 (hr-52) was obtained from the rolling circle amplification-mediated hairpin RNA (RMHR)-based Arabidopsis library in our previous study 19,20

Lane 1: human HepG2 whole cell lysates, Lane 2: human MCF-7 whole cell lysates, Lane 3: human RT4 whole cell lysates, Lane 4: monkey COS-7 whole cell lysates, Lane 5: rat kidney tissue lysates, Lane 6: rat testis tissue lysates, Lane 7: mouse kidney tissue lysates

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Activation of PXR induces the expression of UGT1A1 the enzyme responsible for bilirubin glucuronidationas well as efflux transporters such as MRP2, enhancing bilirubin clearance from the liver